Unable to connect BEX using sap router string

Hi Friends,

How to connect BEX using sap router string.

When I tried to connect BEX using sap router string getting below error:

Error Group

RFC_ERROR_COMMUNICATION

Message

SAP_CMINIT3 : rc=20 > Connect to SAP gateway failed

Connect_PM  GWHOST=192.168.22.21, GWSERV=sapgw74, SYSNR=74

LOCATION    CPIC (TCP/IP) on local host Test-MacBook

ERROR       partner '192.16822.21:3374' not reached

TIME        Wed Jan 13 20:43:39 2016

RELEASE     740

COMPONENT   NI (network interface)

VERSION     40

RC          -10

MODULE      D:/depot/bas/740_REL/src/base/ni/nixxi.cpp

LINE        3324

DETAIL      NiPConnect2: 192.168.22.21:3374'

SYSTEM CALL connect

ERRNO       10060

ERRNO TEXT  WSAETIM

Please do needful.

Regards,

Karthik