RFC Connection error

Hi

When I am trying to open Query Designer then I am getting the following error..

Error Group

RFC_ERROR_COMMUNICATION

Message

SAP_CMINIT3 : rc=20 > Connect to SAP gateway failed

Connect_PM  GWHOST=10.10.2.197, GWSERV=sapgw35, SYSNR=35

LOCATION    CPIC (TCP/IP) on local host IBM578-PK14NBZ

ERROR       partner '10.10.2.197:3335' not reached

TIME        Wed Jun 01 11:59:08 2016

RELEASE     740

COMPONENT   NI (network interface)

VERSION     40

RC          -10

MODULE      D:/depot_hotfix/bas/740_REL/src/base/ni/nixxi.cpp

LINE        3324

DETAIL      NiPConnect2: 10.10.2.197:3335

SYSTEM CALL connect

ERRNO       10060

ERRNO TEXT  WSAET

Please help me in solving this

Thanks in advance